$PROB PK 1 cpt voie orale, eq diff, erreur residuelle mixte
$INPUT ID TIME AMT DV EVID CMT
$DATA ..\data.csv IGNORE=#
$SUBROUTINE ADVAN6 TRANS1 TOL=3
$MODEL NCOMP=2
  COMP=(DIG, DEFDOSE)
  COMP=(CENTRAL, DEFOBS)

$PK
  KA   = THETA(1) * EXP(ETA(1))
  CL   = THETA(2) * EXP(ETA(2))
  V2   = THETA(3) * EXP(ETA(3))
  KE = CL/V2
  S2 = V2

$DES
  DADT(1) = -KA*A(1)
  DADT(2) =  KA*A(1) - KE*A(2)

$ERROR
  IPRED=F
  W=(F*F*THETA(4)**2+THETA(5)**2)**0.5
  Y=F+ERR(1)*W   
  IRES=DV-IPRED  
  IWRES=IRES/W
$THETA
   (0, 2)  ; KA
   (1, 30, 500) ; CL
   (5, 60, 500) ; V2
   (0, .1)      ; PROP
   (0, 500)     ; ADD
$OMEGA 
  .1 ; ETA_KA
  .1 ; ETA_CL
  .1 ; ETA_V2
  
$SIGMA 
  1 FIXED
$EST METHOD=1 INT MAXEVAL=8000 PRINT=5 NOABORT POSTHOC NSIG=3
$COVARIANCE
$TABLE ID TIME DV PRED CMT WRES RES IPRED IWRES IRES FILE=1.fit
$TABLE KA CL V2 FIRSTONLY NOPRINT 
  FILE=parameter.fit