FR

PK 1 compartiment, perfusion, covariables

$PROB 1 cpt perfusion covariables
$DATA ..\data.csv IGNORE=#
$INPUT ID TIME RATE AMT EVID DV WT CREA AGE SEX
$SUBR ADVAN1 TRAN2
$PK
WTM =72 ; poids median de la population
AGEM=43 ; age median de la population
TVCL=THETA(1)*(AGE/AGEM)*(1/CREA)
TVV =THETA(3)*(WT/WTM) + THETA(4)

CL=TVCL* EXP(ETA(1))
V =TVV * EXP(ETA(2))

S1=V

$ERROR
Y=F * (1+ERR(1))

$THETA (0,.1) ; POPCL L/H
$THETA (0,20) ; POPV L
$THETA (0,20) ; POPV L

$OMEGA 0.4 ; BSVCL
$OMEGA 0.3 ; BSVV

$SIGMA 0.1 ; EPS

$ESTIM MAXEVAL=9999 SIGDIG=3 PRINT=10 NOABORT METHOD=CONDITIONAL INTERACTION
$COV

$TABLE ID TIME CL V WT CREA CLCR ONEHEADER NOPRINT FILE=1.fit

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