FR

PK 1 compartiment, bolus intra-veineux

$PROB PK 2 cpts voie intraveineuse
$INPUT ID TIME DV AMT AGE WT CREA
$DATA ..\data.csv IGNORE=#
$SUBR ADVAN1 TRAN2
$PK

CL=THETA(1) *EXP(ETA(1))
V =THETA(2) *EXP(ETA(2))
K=CL/V
S1=V

$THETA (0,0.3) ; POPCL
$THETA (0,5) ; POPV

$OMEGA 0.2 ; BSVCL
$OMEGA 0.1 ; BSVV

$SIGMA 0.05 ; EPS1

$ERROR
DEL=0
IF (F.EQ.0) DEL=1
W=F+DEL
Y=F+W*EPS(1)
IPRED=F
IRES=DV-IPRED
IWRES=IRES/W

$ESTIMATION METHOD=1 FOCE PRINT=5 INTERACTION SIGDIGIT=3 MAXEVAL=2000 POSTHOC
$COVARIANCE
$TABLE ID AMT DV IPRED IRES IWRES ONEHEADER
NOPRINT FILE=base.fit
$TABLE ID CL V AGE WT CREA ONEHEADER
NOPRINT FILE=covariables.fit

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